This platform leverages structure-based rational design and comprehensive signaling assays to create precision therapeutics with enhanced efficacy and reduced desensitization. The platform develops signaling-selective ligands that offer extended receptor activity through reduced desensitization, leading to excellent therapeutic outcomes compared to unbiased approaches.

Our signaling assay systems can quantify pathway-specific activity including cAMP production and β-arrestin-mediated receptor internalization, significantly accelerating discovery compared to traditional screening approaches and ensuring only the most promising candidates advance to clinical development.

This platform overcomes major challenges in developing oral peptide therapeutics by addressing enzymatic degradation and poor gastrointestinal absorption through enhanced molecular stability and advanced formulation technologies.

The platform enables peptides to achieve clinically meaningful exposure by combining rational peptide design with innovative drug delivery strategies that significantly improve absorption across the gastrointestinal tract. This approach simultaneously addresses both peptide stability and absorption challenges, offers versatility across broad peptide structures and disease indications, and integrates proprietary technologies that create robust intellectual property protection.

This platform improves pharmacokinetic properties through fatty acid modification (LipoVantageTM platform) and antibody-peptide conjugation (APCVantageTM platform) to enable extended dosing intervals from weekly to monthly or potentially longer.

The platform enhances patient convenience and compliance by extending peptide half-life through systematic optimization including selection of conjugation sites, refinement of peptide sequences to optimize enzymatic stability, and structural tuning of fatty acids. We utilize various modification strategies offering customized approaches tailored to specific therapeutic demands and integrated pharmacokinetic evaluation systems across multiple species for early identification of optimal modifications.